Invited seminar at the Glasgow Biomaterials seminar series
15.12.2016
Dr Athina Markaki
(Department of Engineering, University of Cambridge)
More about Athina's work: http://www-memti.eng.cam.ac.uk/people/am253@cam.ac.uk
Abstract by Athina Markaki: Transition from Stiff to Compliant Scaffolds
Scaffolds are used as 3-D platforms for both in vitro and in vivo studies of cellular interactions and tissue biosynthesis, as well as in clinical repair of a number of tissues. The talk will focus on relatively stiff, metallic “fibre network materials” (bonded assemblies of fibres), which have the potential for actuation in vivo, to compliant collagen scaffolds. High porosity and pore interconnectivity result in very compliant scaffolds and overstraining during characterisation can lead to misleading results. The talk will focus on study of the various inter-relationships between architecture, mechanical and transport properties, and cell responses.
Papers mentioned in the talk:
J.M. Sobral, V.N. Malheiro, T.W. Clyne, J. Harris, R. Rezk, W. O'Neill, A.E. Markaki, (2015), "An Accelerated Buoyancy Adhesion Assay combined with 3-D Morphometric Analysis for Assessing Osteoblast Adhesion on Microgrooved Substrata", Journal of the Mechanical Behaviour of Biomedical Materials, in press.
R.L. Spear, A. Symeonidou, J.N. Skepper, R.A. Brooks, A.E. Markaki (2015), "Fibrin affects Short-term In Vitro Human Mesenchymal Stromal Cell Responses to Magneto-active Fibre Networks", Biomaterials and Biomedical Engineering, 2(3), pp. 143-157.
A.C. de Luca, M. Zink, A. Weidt, S.G. Mayr, A.E. Markaki (2015), "Effect of Microgrooved Surface Topography on Osteoblast Maturation and Protein Adsorption", Journal of Biomedical Materials Research: Part A, 103(8), pp. 2689-700.
R.L. Spear, B. Srigengan, S. Neelakantan, W. Bosbach, R.A. Brooks, A.E. Markaki (2015), "Physical and Biological Characterisation of Ferromagnetic Fibre Networks: Effect of Fibrin Deposition on Short-term In Vitro Responses of Human Osteoblasts", Tissue Engineering Part A, 21(3-4), pp. 463-474.
A.E. Markaki and T.W. Clyne (2005), “Magneto-Mechanical Actuation of Bonded Ferromagnetic Fibre Arrays”, Acta Materialia, 53(3), pp. 877-889.
A.E. Markaki and T.W. Clyne (2004), “Magneto-Mechanical Stimulation of Bone Growth in A Bonded Array of Ferromagnetic Fibres”, Biomaterials, 25(19), pp. 4805-4815.
H.J. Griffiths, A.E. Markaki, C.A. Collier, T.W. Clyne (2011), “Cell Adhesion to Plasma Electrolytic Oxidation (PEO) Titania Coatings, Assessed using a Centrifuging Technique”, Journal of the Mechanical Behaviour of Biomedical Materials, 4(8), pp. 2103-2112.
A.E. Markaki and A.W. Justin (2014), "Magneto-Active Scaffold for Stimulation of Bone Growth”, Invited Review, Special Issue on Smart Materials, Materials Science & Engineering, 30 (13a), pp. 1590-1598.
S. Neelakantan, W. Bosbach, J. Woodhouse, A.E. Markaki (2014), "Characterisation and Deformation Response of Orthotropic Fibre Networks with Auxetic Out-Of-Plane Behaviour", Acta Materialia, 66, pp. 326-339.
V.N. Malheiro, J.N. Skepper, R.A. Brooks, A.E. Markaki (2013), "In vitro Osteoblast Response to Ferritic Stainless Steel Fibre Networks for Magneto-Active Layers on Implants", Journal of Biomedical Materials Research: Part A, 101(6), pp. 1588-1598.
R.L. Spear, R.A. Brooks, A.E.Markaki (2013), "Short-term In vitro Responses of Human Peripheral Blood Monocytes to Ferritic Stainless Steel Fibre Networks", Journal of Biomedical Materials Research: Part A, 101(5), pp. 1456-1463.
V.N. Malheiro, R.L. Spear, R.A. Brooks, A.E. Markaki (2011), “Osteoblast and Monocyte Responses to 444 Ferritic Stainless Steel intended for a Magneto-Mechanically Actuated Fibrous Scaffold”, Biomaterials, 32(29), pp. 6883-6892.
D. Tsarouchas & A.E. Markaki (2011), “Extraction of Fibre Network Architecture by X-ray Tomography and Prediction of Elastic Properties using an Affine Analytical Model”, Acta Materialia, 59(18) pp. 6989-7002.